血小板粘附和活化是血液接触生物材料上形成血栓或凝块的重要成因。因此,了解生物材料表面特性与血小板之间的复杂相互作用,对于开发能够预防血栓的血管通路装置具有重要意义。医用级聚氨酯材料因其良好机械性能和出色血液相容性,常用于接触血液的医疗器械中。此外,研究发现亚血小板大小的微结构可以减少血小板粘附。基于这一证据,我们假设生物医学热塑性聚氨脂(TPU)结合防生物沉积的Sharklet™(SK)仿生微结构比平滑表面(SM)更能够减少血小板粘附和活化。

Hot embossing biomedical TPU produced micropatterned and SM controls with identical surface chemistries to facilitate the evaluation of the influence of surface microtopography on platelet adhesion and activation. SK microtopographies reduced platelet adhesion by 86%, p=0.007 compared to SM controls. Similarly, platelet activation as measured by average individual platelet area was reduced significantly (68%, p=0.002) on the SK pattern compared to SM. Here, we demonstrate that the application of engineered surface microtopographies to blood-contacting medical devices such as CVCs could further improve blood-biomaterial interactions and thus hemocompatibility without the application of anticoagulant coatings. Incorporating this technology into medical devices could also improve patient safety by reducing in-hospital morbidity, mortality and treatment costs.

Full paper: http://www.clintransmed.com/content/pdf/s40169-015-0050-9.pdf